One of the first lncRNA to be discovered was the Xist lncRNA which plays an important role in X chromosome inactivation (Penny et al., 1996), an extreme case of genomic imprinting. lncRNAs are present at almost all imprinted loci, arguing for an important role for
Nov 01, 2012 · THE past several years have witnessed a steep rise of interest in the study of lncRNAs. Almost on a weekly basis, it seems that a new lncRNA is found to be up- or downregulated in a particular disease, or a new class of noncoding transcripts is uncovered by a transcriptomic study, or a new article heralds a paradigm shift that lncRNAs will bring to our understanding of biology.
Cited by: 1182
Nov 18, 2019 · Xu, H., Jiang, Y., Xu, X. et al. Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing
Author: Henan Xu, Henan Xu, Yan Jiang, Xiaoqing Xu, Xiaoping Su, Yang Liu, Yuanwu Ma, Yong Zhao, Zhongyang S
lncRNA Research and Industry News. Long non-coding RNAs (long ncRNAs, lncRNA) are non-protein coding transcripts longer than 200 nucleotides.
Aug 18, 2016 · Many long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in hepatocellular carcinoma (HCC), and may have the potential to serve as prognostic markers. In this study, a meta-analysis was conducted to systematically evaluate the prognostic value of various lncRNAs in HCC. High expressions of lncRNA-ATB and MALAT1 can
Cited by: 3
Dec 19, 2017 · Mechanisms of viral infection are active areas of investigation. In a recent issue of Science, Wang et al. (2017) reveal an additional function of a host-encoded long non-coding RNA (lncRNA) in regulating viral expression by binding a host metabolic enzyme to
Cited by: 1
Dec 20, 2017 · 接下来从以下8个方面来介绍：LncRNA的定义、LncRNA的发现、LncRNA的分类、LncRNA的功能、LncRNA的作用模式、LncRNA的争议、LncRNA的常用数据库以及LncRNA的研究模式。一 生信技能树
长链非编码RNA(Long non-coding RNA, lncRNA)是长度大于 200 个核苷酸的非编码 RNA。研究表明, lncRNA 在剂量补偿效应(Dosage compensationeffect)、表观遗传调控、细胞周期调控和细胞分化调控等众多生命活动中发挥重要作用，成为遗传学研究热点。
lncRNA功能示意图 来源：Yang G, Lu X, Yuan L. LncRNA: A link between RNA and cancer[J]. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 2014. LncRNA作用机制. 长链非编码RNA的作用机制非常复杂，至今尚未完全清楚。根据目前的研究，lncRNA的作用机制如要有以下几种。
Sense lncRNA. Sense lncRNAs are transcribed from the sense strand of protein-coding genes and contain exons from protein-coding genes that overlap with part of protein-coding genes or cover the entire sequence of a protein-coding gene through an intron. 4. Antisense lncRNA
LncRNA SUMO1P3 has been documented as an oncogene promoting proliferation, cell cycle, and metastasis in several cancers, but its role in CRC has never been unveiled. The purpose of our study is to interrogate the functions and mechanism of SUMO1P3 in colorectal cancer. We validated the upregulation and the prognostic significance of SUMO1P3 in
Welcome to Arraystar Inc – Go Beyond RNA. Arraystar uses cutting edge science, state of the art technologies, and innovative products to empower biomedical science researchers.
3.3. Knockdown of lncRNA PCAT1 markedly inhibits EC migration and invasion. To further investigate the function of lncRNA PCAT1 in endometrial carcinoma, we utilized three approaches including wound healing, Transwell with and without Matrigel to inspect cell behaviors under the condition of lacking lncRNA PCAT1 in KLE and AN3CA cell lines.
The Bio-Rad lncRNA RT-qPCR workflow enables highly sensitive detection of lncRNAs by RT-qPCR. This innovative workflow was specifically developed to help overcome unique challenges associated with lncRNA expression analysis, including the low-expression levels of lncRNAs and difficulties with lncRNA primer design and validation. When used together, these products offer guaranteed performance
A promising route to develop new treatments for skin cancer has been identified by University of Bath scientists, who have found a molecule that suppresses melanoma tumour growth. Although the research is at an early stage, the team hope that their work could help develop new ways to combat melan
2 日前 · Next, we constructed two lncRNA–miRNA–mRNA networks using Cytoscape based on the targeting relationship between differentially expressed miRNAs (DEMs) and DEGs and differentially expressed lncRNAs (DELs) analyzed by TargetScan and miRanda.
MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus. Yanqiang Wang, Huiling He, Wei Li, John Phay, Rulong Shen, Lianbo Yu, Baris Hancioglu, and Albert de la Chapelle. PNAS January 17, 2017 114 (3) 474-479; first published January 3, 2017.
Abstract. Prostate cancer (PCa) is a devastating malignant disease with a poor prognosis. The aim of current study is to investigate the role of lncRNA-urothelial carcinoma associated 1 (UCA1) in the progression of PCa. We evaluated the expression levels of UCA1 in a total of 16 benign prostatic hyperplasia tissues (BPH) and 40 PCa tissues, as well as PCa cells. The functional regulatory
Cited by: 1
In our epidemiology study, nine single‐nucleotide polymorphisms (SNPs) in lncRNA LINC00520 were selected for genotyping among 504 breast cancer cases and 505 healthy controls. The 504 cases are all
However, the molecular mechanisms underlying these interactions are still largely unknown. In this study, these lncRNA-miRNA-gene interactions were defined as lncRNA-associated competing triplets (LncACTs), and an integrated pipeline was developed to identify lncACTs that are active in cancer.
The key difference between lincRNA and lncRNA is the length of the RNA. That is; the lincRNAs are long strands of RNA whereas lncRNAs are comparatively short strands of RNA.. RNA or Ribonucleic acid is an important biomolecule which has varied functions. There are many new discoveries taking place in terms of RNA. lincRNA and lncRNA are two such new discoveries. lincRNA stands for Long
Ideal for reliably quantitating transcripts longer than 200 nucleotides, detect only the intended noncoding RNA transcript, assays are based on proven TaqMan® Assay technology and use existing assay design and manufacturing infrastructure, Long noncoding RNA (ncRNA) Analysis Using Real-Time PCR.
長鎖ノンコーディングRNA（long noncoding RNA、lncRNA） 長鎖ncRNAは多様な機能を担っていることが明らかにされているが、これまでに解析された例の多くは、核内構造体構築あるいはエピジェネティック制御に関与している。
Jun 03, 2019 · Many tumors evade immunosurveillance by down-modulating expression of antigen-processing machinery and MHC molecules. Yang et al. report triple-negative tumor cell expression of the lncRNA LINK-A
Cited by: 6
nrStar™ Functional LncRNA PCR Arrays profile 372 Human/185 Mouse lncRNAs with known biological functions or disease associations. It offers simple & accurate lncRNA profiling with rich annotations to explore LncRNA functions and biomarker potentials.
Oct 21, 2015 · Genetics professor, Ahmad Khalil, is here to explain the role of long non-coding RNAs in the realm of cancer and epigenetics.
Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and could be a potential therapeutic target. We screened highly expressed lncRNAs in human CRC samples compared with their matched adjacent normal tissues. The proteins that interact with LINRIS
Novogene’s bioinformatics team provides comprehensive analysis for both lncRNAs and mRNAs, enabling access to lncRNA and mRNA information in a single sequencing run. Applications include comparison of lncRNA and mRNA expressions in different stages of development and in different tissues, as well as unveiling key functions of mRNAs and lncRNAs.
Jan 23, 2018 · Numerical support for upward trending interest in lncRNA is provided by the chart shown here for the number of annual publications on lncRNA. This chart was produced by using data I found in PubMed for 2000-2016, which clearly show a relatively flat rate of ~150 papers per year from 2000-2007, and then an exponential increase to ~2,220 papers in 2016.
LncRNA expression proﬁles may be useful as biomarkers for cancer diagnosis. • Alpha-Thalassaemia An inherited form of this type of anemia is caused by the translocation of of an antisense lncRNA near the alpha-globin gene, resulting in the epigenetic silencing of the HBA2 gene and causing the disease. • Alzheimer’s Disease
クリックして Bing でレビューする4:04
Feb 18, 2018 · For more information, visit: https://www.bio-rad.com/lncRNA Subscribe to the Bio-Rad channel: https://www.youtube.com/user/BioRadLi Learn about the exciting new
著者: Bio-Rad Laboratories
lncRNA scripts for Shea et al. 2019 Long noncoding RNAs in Brassica rapa L. following vernalization. Scientific Reports doi:10.1038/s41598-019-45650-w – danshea/lncRNA
The gene coding for BC200 lncRNA is BCYRN1 (brain cytoplasmic RNA 1). A repeat polymorphism of cytosines and adenines (CA) was found to be near BCYRN1 and was used as a reference for mapping the gene. Linkage mapping and radiation hybrid mapping localized the BCYRN1 gene to chromosome 2p16.. As a long non-coding cytoplasmic RNA, BC200 RNA is a part of the largest group of non
Dec 28, 2016 · “We show that the SPAR-encoding lncRNA is highly expressed in a subset of tissues and use CRISPR/Cas9 engineering to develop a SPAR-polypeptide-specific
Long non-coding RNA (lncRNA) is a large class of gene transcripts with regulatory functions discovered in recent years. Many more are expected to be revealed with accumulation of RNA-seq data from diverse types of normal and diseased tissues.
RNA Antisense Purification followed by RNA-Sequencing is a method to map the RNA interactions that occur with a specific lncRNA (or other RNA species). Using different crosslinking methods, this approach can be used to identify lncRNA-RNA interactions that occur through protein intermediates or through direct RNA-RNA hybridization.
May 31, 2019 · Review Long non-coding RNA the top 100+ protocol, troubleshooting and other methodology questions with answers | Contact experts in Long non-coding RNA to get answers
We then integrated the FANTOM5 CAGE datasets with transcript models from diverse sources, and built a meta-assembly called FANTOM CAGE associated transcriptome (FANTOM CAT). Comparing with GENCODE, FANTOM CAT contains 19,688 more lncRNA loci and their 5’ ends are better supported with epigenome evidence.
Lnc2Cancer, is a manually curated database that provides comprehensive experimentally supported associations between lncRNA and human cancer. The current version of Lnc2Cancer documents 4,989 entries of associations between 1,614 human lncRNAs and 165 human cancer subtypes through review of more than 6,500 published papers.
Nov 22, 2018 · Arraystar Human LncRNA Microarray v4.0, performed by Arraystar Inc. (Rockville, MD, USA), is designed for the global expression profiling of 40 173 human lncRNA and 20,730 protein-coding mRNA transcripts. HUVECs were transfected with 10 nM control GapmeRs or Meg3 GapmeRs and treated with 10 ng/ml TNF-α for 3 h.
Jan 27, 2020 · LncRNA AC093818.1 may be a potential therapeutic target for metastatic GC. Gastric cancer (GC) is a highly prevalent type of metastatic tumor. The
Dec 03, 2019 · Aberrant lncRNA expression is responsible for cancer progression and metastasis, positioning lncRNAs not only as biomarkers but also as promising therapeutic targets for curing cancer. A number of lncRNAs have been reported in ESCC but their mechanistic roles largely remain unknown. Wnt signaling pathways are often dysregulated in ESCC; however, the role of lncRNAs in such
a The lncRNA Firre is transcribed from the X chromosome (chrX) and, by binding hnRNP-U, acts as a platform for trans-chromosomal interactions . b The lncRNA NEAT1 functions as an essential structural determinant for the assembly of paraspeckles.
Jun 08, 2019 · Abstract. Background: Dysregulated expression of long non-coding RNA gastric carcinoma high expressed transcript 1 (lncRNA GHET1) has been observed in several cancers, however, definite conclusion on the prognostic value of lncRNA GHET1 expression in human cancers has not been determined. The aim of this meta-analysis was to evaluate the prognostic significance of lncRNA
Recently, the roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in human diseases have been unveiled, this research was conducted to explore the impacts of lncRNA SET-binding factor 2-antisense RNA1 (SBF2-AS1), miR-143 and resistance to ralstonia solanacearum 1 (RRS1) on breast cancer (BC) development. The expression of SBF2-AS1, miR-143 and RRS1 in BC tissues, as well as
Welcome to lncRNA.smu.edu.cn ! This website currently consists of two software – LongTarget and LongMan. LongTarget was developed to predict a lncRNA’s DNA binding motifs and binding sites in a genomic region based on potential base pairing rules between a RNA sequence and a DNA duplex.
Research Article lncRNA IGHCγ1 Acts as a ceRNA to Regulate Macrophage Inflammation via the miR-6891-3p/TLR4 Axis in Osteoarthritis Pengjun Zhang,1,2 Jianmei Sun,3 Caihong Liang,4 Bingjie Gu,5 Yang Xu,6 Hongying Lu,7 Bo Cao ,8 and Hao Xu 1 1Department of Joint Surgery, The Aﬃliated Hospital of Qingdao University, Qingdao University, Qingdao 266100, China 2Department of Emergency
Antisense – The lncRNA sequence overlaps with the antisense strand of a protein coding gene. Bidirectional – The lncRNA sequence is located on the opposite strand from a protein coding gene whose transcription is initiated less than 1000 base pairs away. Intronic – The lncRNA sequence is derived entirely from within an intron of another transcript.
The ultimate demonstration of the functional contribution of a lncRNA is through genetic testing. If DNA containing a lncRNA is removed and the organism is affected, then it must be important, no matter its molecular mode of action.
Increasing amounts of evidence indicate that noncoding RNAs (ncRNAs) have important roles in various biological processes. Here, miRNA, lncRNA, and mRNA expression profiles were analyzed in human HepG2 and L02 cells using high-throughput technologies. An integrative method was developed to identify possible functional relationships between different RNA molecules. The dominant deregulated
Citation: Feng C, Shen JM, Lv PP, Jin M, Wang LQ, Rao JP, Feng L. Construction of implantation failure related lncRNA-mRNA network and identification of lncRNA
lncRNA-mRNA network and identification of lncRNA biomarkers for predicting endometrial receptivity Chun Feng1* , Jin-Ming Shen2*, Ping-Ping Lv3, Min Jin1, Li-Quan Wang1, Jin-Peng Rao1, and Lei Feng2 1. The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. 2.
This lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition, CCAT1-L interacts with CTCF